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Medchemexpress LLC DOPE | 4004-05-1 | 99.96% | 744.03 | 50 MG
Supplier: Medchemexpress LLC HY11200550MG
DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid that combines with cationic phospholipids to improve the transfection efficiency of naked siRNA, and it is also an endogenous metabolite. In studies, DOPE-containing liposomes (LNP) exhibited a knock-down (KD) effect on macrophages and dendritic cells and showed fusogenicity. LNP/siRNA significantly suppressed CD45 protein expression, demonstrating potential as an efficient siRNA delivery system for both murine and human macrophages and dendritic cells.
- Neutral helper lipid for cationic liposomes
- Improves transfection efficiency of naked siRNA
- Exerts knock-down (KD) effect on macrophages and dendritic cells
- Liposomes containing DOPE show fusogenicity
- Potential for efficient siRNA delivery system
- Endogenous metabolite
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