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STEMCELL Technologies Dorsomorphin, Size: 10 mg
Supplier: STEMCELL Technologies 72102
Dorsomorphin inhibits the bone morphogenetic protein (BMP) pathway by targeting the type I BMP receptors activin receptor-like kinase (ALK) 2, ALK3, and ALK6. It is also a potent inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM) but does not significantly inhibit structurally related kinases such as ZAPK, SYK, PKCθ, PKA, or JAK3 (Bain et al., Yu et al.). DIFFERENTIATION· Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Morizane et al., Zhou et al.).· Promotes differentiation of cardiomyocytes from mouse and human pluripotent stem cells (Hao et al., Kattman et al.).· Promotes differentiation of adipocytes and suppresses osteogenic differentiation of osteoblasts from human mesenchymal cells (Kim et al.).
Safety and Handling
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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