Medchemexpress LLC Dosimertinib-d5 mesylate | 2403760-72-3 | 99.4% | C29H32D5N7O5S | 1 MG

Supplier:  Medchemexpress LLC HY142283AS1MG

Dosimertinib-d5 (mesylate) is a potent, orally active Epidermal Growth Factor Receptor (EGFR) inhibitor. It decreases the expression of p-EGFR and p-ERK protein levels, demonstrating antiproliferative and anti-tumor activity. It has potential for research into non-small-cell lung cancer (NSCLC).

• Potent and orally active EGFR inhibitor.
• Decreases p-EGFR and p-ERK protein levels.
• Antiproliferative and anti-tumor activity.
• Suitable for use as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
• Decreases p-EGFR and p-ERK protein levels in A431 and H1975 cells in a dose-dependent manner.
• Shows anti-tumor activity in BALB/c nude mice with H1975 xenograft model.
• Soluble in DMSO at 100 mg/mL (166.46 mM), requiring ultrasonic and warming to 80°C.

Catalog No. 50-003-54374