Abcam Dovitinib, class III-V receptor tyrosine kinase inhibitor, 5MG

Supplier:  Abcam AB2163125MG

MW 392.4 Da, Purity >99%. Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC₅₀ = 1 nM), c-KIT (IC₅₀ = 2 nM), FGFR (IC₅₀ = 8 nM), VEGFR1/2/3 (IC₅₀ values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC₅₀ = 27 nM), and CSF-1R (IC₅₀ = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.

The product is subject to the following: Abcam Restricted Use Statement

Catalog No. 50-267-6656