Doxycycline hyclate

Description

Doxycycline hyclate, Doryx, CAS # 24390-14-5, is the hyclate salt form of the broad-spectrum antibiotic known as doxycycline. | CAS: 24390-14-5 | C26H41ClN2O12 | 609.066 g/mol

Inhibits matrix metalloproteinases at subantimicrobial doses.Doxycycline hyclate is an antibacterial antibiotic, which is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description
• Doxycycline hyclate is a broad-spectrum bacteriostatic antibiotic of the tetracycline class
• Doxycycline inhibits bacterial growth by preventing polypeptide formation via inhibition of at least one ribosomal subunit
• Known to reversibly bind the 30S ribosomal subunit and inhibit formation of the aminoacyl-tRNA/mRNA-ribosome complex
• Inhibits matrix metalloproteinases in many microorganisms
Applications
• Effective against the bacteria that cause Lyme disease, chlamydia, rickettsia and mycoplasma; suitable for antibiotic resistance testing and study of cellular mechanisms
• Intended for laboratory use only

Specifications

Chemical Identifiers

• CAS: 24390-14-5
• Molecular Formula: C26H41ClN2O12
• Molecular Weight (g/mol): 609.066
• MDL Number: MFCD07357237
• InChI Key: ISZOFWGVNMFENH-YDLUHMIOSA-N
• PubChem CID: 131676157
• IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;ethanol;dihydrate;hydrochloride
• SMILES: CCO.CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.O.Cl

• Type: Doxycycline Hyclate
• Physical Form: Powder
• Color: Yellow
• Quantity: 25 g
• Merck Index: 14,3440
• Synonym: Hydramycin; Doxycycline hydrochloride hemiethanolate hemihydrate
• Solubility Information: Soluble in water to 50mg/ml; May require warming;Soluble in water,methanol; Sparingly soluble in ethanol; Insoluble in chloroform and ether.
• Formula Weight: 512.94 (503.94 Anhydrous)
• Chemical Name or Material: Doxycycline hyclate

Safety and Handling

Hazard Category	H302-H315-H319-H335-H361fd
Hazard Statement	GHS H Statement H302-H315-H319-H335 Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c
RTECSNumber	QI8925000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only