Cayman Chemical DPTIPhydrochlorIde 10mg

Supplier:  Cayman Chemical 4168110 MG

An nSMase2 inhibitor (IC50 = 30 nM); selective for nSMase2 over ALP and acid sphingomyelinase (IC50s = >100 µM for both); reduces viral yield in Vero and HeLa cells infected with West Nile virus (EC50s = 0.26 and 2.81 µM, respectively) or Zika virus (EC50s = 1.56 and 1.84 µM, respectively); prevents serum deprivation-induced astrocyte activation in primary rat astrocytes at 10 µM; reduces IL-1β-induced extracellular vesicle release from astrocytes, decreases neutrophil infiltration to the brain, and reduces hepatic levels of Ccl2, Tnf-α, Il-6, and Il-1β in a GFAP-GFP mouse model of inflammation-induced brain injury at 10 mg/kg

Catalog No. 50-294-5875