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Medchemexpress LLC DRB18 | 2863686-81-9 | 99.6% | C22H23ClN2O2 | 100 MG
Supplier: Medchemexpress LLC HY145963100MG
DRB18 is a potent pan-class GLUT inhibitor that alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. It can lead to G1/S phase arrest, increase oxidative stress, and cause necrotic cell death, while also exhibiting anti-tumor activity.
- Potent pan-class GLUT inhibitor
- Alters energy-related metabolism in A549 cells
- Leads to G1/S phase arrest
- Increases oxidative stress
- Causes necrotic cell death
- Exhibits anti-tumor activity
- Reduces glucose uptake in GLUT1-4-expressed HEK293 cell lines
- Decreases expression of GLUT1-4 in xenografted tumors
- Reduces proliferative capacity within xenografted tumors
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