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Medchemexpress LLC Dronedarone Hydrochloride | 141625-93-6 | 99.99% | C31H45ClN2O5S | 50 MG
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Supplier:  Medchemexpress LLC HY7583950MG

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Dronedarone Hydrochloride is a non-iodinated amiodarone derivative acting as a multichannel blocker for atrial fibrillation. It inhibits Na+, K+, and Ca2+ currents and is a potent inhibitor of acetylcholine-activated K+ current, rapid delayed rectifier, and L-type calcium current.

  • Inhibits human Kv1.5 channel with an IC50 of 2.37 μM.
  • Blocks IKr (IC50=3 μM) and ICa-L (IC50=0.18 μM).
  • Exhibits state-dependent inhibition of fast Na+ channel current.
  • Reduces incidence of ventricular fibrillation (VF) in rats.
  • Inhibits carotid artery thrombus formation in vivo.
  • Impairs thrombin- and collagen-induced platelet aggregation.
  • Reduces expression of plasminogen activator inhibitor-1 (PAI1).

Catalog No. 50-004-33779


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