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Medchemexpress LLC DS-1001b | 1898207-64-1 | 99.7% | 50 MG
Supplier: Medchemexpress LLC HY12954550MG
DS-1001b is an orally active, blood-brain permeable, potent IDH-1 (isocitrate dehydrogenase-1) mutant inhibitor with antitumor activity. It targets IDH-1 and shows promise in various biological activities.
- Orally active and blood-brain permeable
- Potent IDH-1 mutant inhibitor
- Exhibits antitumor activity
- Inhibits proliferation of IDH1-mutated chondrosarcoma cells
- Upregulates SOX9, RUNX2, COL2A1, COL10A1, and ACAN expression
- Induces G1 phase arrest
- Damages subcutaneous tumor growth in xenografted mice
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