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Medchemexpress LLC Dspe-peg2000-crgdkgpdc (disulfide bridge:Cys1-Cys9) | 95.0% | 2000 (Average) | 25 MG
Supplier: Medchemexpress LLC 25MGHY172494
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and an αv-integrins targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and is then proteolytically cleaved in the tumor to produce CRGDK/R, which interacts with neuropilin-1. This compound has tumor-targeting and tumor-penetrating properties and can be used for agent delivery.
- Irgd peptide binds to αv-integrins.
- Proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1.
- Possesses tumor-targeting and tumor-penetrating properties.
- Can be used for agent delivery.
- Used to construct nanomicelles for targeted delivery of salinomycin to intervene in liver cancer cells and cancer stem cells.
- Used to construct a tumor-penetrating peptide liposome that exhibits antitumor effects, including a significant reduction in tumor volume and an increase in body weight and spleen index.
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