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Medchemexpress LLC DSPE-PEG2000-Mal-Cys-YHWYGYTPQNVI | 95.3% | 2000 (Average) | 50 MG
SDP

Supplier:  Medchemexpress LLC HY17247050MG

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DSPE-PEG2000-GE11 is a nanocarrier component composed of DSPE and the EGFR-targeting peptide (GE11). It specifically binds to EGFR, mediating receptor-mediated endocytosis of micellar drug carriers for drug delivery.

  • Specifically binds to EGFR.
  • Mediates receptor-mediated endocytosis of micellar drug carriers.
  • Enhances EGFR-dependent cellular uptake of doxorubicin (1.4-fold higher in SMMC-7721 cells).
  • Inhibits HUVEC proliferation, induces G2-M phase arrest, reduces cell migration, and alters HUVEC morphology when modified.
  • Enhances tumor accumulation of DiR-loaded micelles in EGFR-positive hepatocellular carcinoma xenografts.
  • Confers EGFR-targeted accumulation to liposomal formulations in liver cancer xenografts.

Catalog No. 50-003-85010


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