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Medchemexpress LLC DSPE-PEG4-DBCO | 2112738-14-2 | 95.0% | C71H116N3O15P | 25 MG
Supplier: Medchemexpress LLC 25MGHY140955
DSPE-PEG4-DBCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its DBCO group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs themselves are composed of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other targets a specific protein. These PROTACs leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Peg-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules
- Used in the synthesis of PROTACs
- PROTACs utilize the ubiquitin-proteasome system for selective protein degradation
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