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Medchemexpress LLC Duloxetine | 116539-59-4 | 99.9% | 5 MG
Supplier: Medchemexpress LLC HYB01615MG
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM. It is used for the treatment of major depressive disorder and generalized anxiety disorder (GAD). It inhibits the reuptake of serotonin and norepinephrine in the central nervous system and is a less potent inhibitor of dopamine reuptake. Its analgesic properties are attributed to sodium ion channel blockade.
- Selective reuptake inhibitor at 5-HT and NA transporters
- Less potent inhibitor of dopamine reuptake
- No significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors
- Potential to decrease pro-inflammatory cytokine activity and increase anti-inflammatory cytokines
- Analgesic properties for conditions like diabetic neuropathy and fibromyalgia
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