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Apexbio Technology LLC DuP 697 88149-94-4 10mg
Supplier: Apexbio Technology LLC B673710
DuP 697 (CAS 88149-94-4) is an ortho-diaryl heterocyclic compound that selectively and irreversibly inhibits cyclooxygenase-2 (COX-2) displaying an IC50 of 10 nM for human COX-2 and 800 nM for COX-1 DuP 697 is demonstrated to suppress prostaglandin synthesis and in vitro exhibits antiproliferative pro-apoptotic and anti-angiogenic effects in HT29 colorectal cancer cells (IC50 42 8 nM) This small molecule is commonly utilized to explore COX-2-mediated inflammatory pathways as well as tumor biology providing a valuable tool for dissecting mechanisms underlying inflammation and cancer
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