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Medchemexpress LLC DX600 | 478188-26-0 | 99.7% | 3074.33 | 5 MG
SDP

Catalog No. 5000423003
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DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE. It has been shown to exacerbate diabetes-induced cardiovascular dysfunction and increase cardiac and renal NOX activity.

  • Selective ACE2 specific inhibitor (KD: 1.3 nM)
  • Does not cross-react with ACE
  • Inhibits rhACE2 activity by 47% at 1 μM
  • Inhibits ACE2 activity by 42% in human MNCs at 10 μM
  • Decreases NR 8383 cell growth and increases TNF-a and IL-6 content at 100 nM
  • Exacerbates diabetes-induced cardiovascular dysfunction in diabetic rats
  • Increases thrombus weight by 30% in a thrombosis model in rats

Catalog No. 50-004-23003 Supplier Medchemexpress LLC Supplier No. HYP22225MG
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DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE. It has been shown to exacerbate diabetes-induced cardiovascular dysfunction and increase cardiac and renal NOX activity.

  • Selective ACE2 specific inhibitor (KD: 1.3 nM)
  • Does not cross-react with ACE
  • Inhibits rhACE2 activity by 47% at 1 μM
  • Inhibits ACE2 activity by 42% in human MNCs at 10 μM
  • Decreases NR 8383 cell growth and increases TNF-a and IL-6 content at 100 nM
  • Exacerbates diabetes-induced cardiovascular dysfunction in diabetic rats
  • Increases thrombus weight by 30% in a thrombosis model in rats

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