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Medchemexpress LLC Dynole 2-24 | 1416313-72-8 | 99.1% | C24H41N3 | 25 MG
Supplier: Medchemexpress LLC 25MGHY145080
Dynole 2-24 is an indole-based dynamin GTPase inhibitor with an IC₅₀ of 0.56 μM for dynamin I. This compound is non-toxic and demonstrates increased potency against dynamin I and II both in vitro and within cells, with an IC₅₀ (CME) of 1.9 μM. It exhibits a 4.4-fold selectivity for dynamin I. Dynole 2-24 acts as an active in-cell inhibitor of clathrin-mediated endocytosis (CME).
- Indole-based dynamin GTPase inhibitor.
- IC₅₀ of 0.56 μM for dynamin I.
- Nontoxic.
- Increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM).
- Shows 4.4-fold selectivity for dynamin I.
- Active in-cell inhibitor of clathrin-mediated endocytosis.
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