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AdipoGen DYRK1A/B Inhibitor AnnH75 (500 µg)
SDP

Supplier:  AdipoGen AGCR13651C500

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Chemical. Formula: C14H10ClN2O. MW: 271.7. Synthetic. Potent selective membrane-permeable DYRK1A (IC50=181nM) and DYRK1B inhibitor. Off-target inhibition of CLK1, CLK4 and Haspin/GSG2. Shows no inhibitory effects on monoamine oxidase A (MAO A). Inhibited the cotranslational tyrosine autophosphorylation of DYRK1A and threonine phosphorylation of an exogenous substrate protein with similar potency. Dose-dependently reduced the phosphorylation of three known DYRK1A substrates (SF3B1, SEPT4 and tau) without negative effects on cell viability in celular assays. Moderate inhibitor of CDK8, CLK2, GRK4, MEK2, PIM1, PIM3 and PKCepsilon. Shows minimal cytotoxic effects in HeLa and PC12 cells up to 10µM.

Catalog No. 50-205-4026


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