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Medchemexpress LLC (E)-1-[(2R)-2-(2-hydroxyethyl)piperidin-1-yl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 10 MG
SDP

Catalog No. 5000243908
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FK 453 is a potent, selective adenosine A1 receptor antagonist intended for research use. It inhibits human A1 receptor activity with an IC50 of 17.2 nM, appears as an off-white to light yellow solid, and also shows activity at adenosine A2B and in primary rat hepatocytes.

  • Potent adenosine A1 receptor antagonist (IC50 17.2 nM).
  • Additional activity at adenosine A2B (cAMP accumulation IC50 0.98 μM).
  • Inhibits NECA-induced glucose production in primary rat hepatocytes (IC50 8.1 μM).
  • High purity: 99.2%.
  • Molecular weight: 375.46.
  • Off-white to light yellow solid; soluble in DMSO (100 mg/mL).
  • Storage recommendations: powder -20°C (3 years); in solvent -80°C (6 months).

Catalog No. 50-002-43908 Supplier Medchemexpress LLC Supplier No. HY105275A10MG
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FK 453 is a potent, selective adenosine A1 receptor antagonist intended for research use. It inhibits human A1 receptor activity with an IC50 of 17.2 nM, appears as an off-white to light yellow solid, and also shows activity at adenosine A2B and in primary rat hepatocytes.

  • Potent adenosine A1 receptor antagonist (IC50 17.2 nM).
  • Additional activity at adenosine A2B (cAMP accumulation IC50 0.98 μM).
  • Inhibits NECA-induced glucose production in primary rat hepatocytes (IC50 8.1 μM).
  • High purity: 99.2%.
  • Molecular weight: 375.46.
  • Off-white to light yellow solid; soluble in DMSO (100 mg/mL).
  • Storage recommendations: powder -20°C (3 years); in solvent -80°C (6 months).

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