Medchemexpress LLC (E)-5-fluoro-N-(3-(3-(hydroxyamino)-3-oxoprop-1-en-1-yl)-4-methoxybenzyl)-2-morpholinoben | 3031349-25-1 | 95.0% | 429.44 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY149029

This potent HDAC inhibitor demonstrates IC50s for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, and inhibits cell migration and invasion. It induces apoptosis and cell cycle arrest at the G2/M phase, also showing anti-tumor activity.

• Potent inhibition of HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8.
• Inhibits cell migration and invasion, and induces apoptosis and cell cycle arrest at G2/M phase.
• Demonstrates anti-tumor activity.
• Inhibits tubulin polymerization.
• Increases expression of acetylated-α-tubulin and acetyl-histone H3.
• Modulates mitochondrial membrane potential and reactive oxygen species levels.
• Exhibits favorable liver microsomal stability.
• Shows antiproliferative activities in various cancer cell lines.
• Demonstrates antivascular activity and good cardiovascular safety in vivo.
• Reduces tumor weights in allograft mouse models.

Catalog No. 50-003-63477