AdipoGen E-64

Supplier:  AdipoGen AGCP37006M025

Chemical. CAS 66701-25-5. Formula C15H27N5O5. Molecular Weight 357.4. The epoxysuccinyl peptide E-64 is an irreversible, potent, and highly selective cysteine protease inhibitor. It inhibits a variety of cysteine proteases, including cathepsins K, L, S, B and H. It inhibits also papain, calpain, ficin and bromelain. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteases except reversible inhibition of trypsin like other cysteine protease inhibitors, e.g. leupeptin and antipain. E-64 is a very useful cysteine protease inhibitor for use for in vitro and in vivo studies because it shows specific inhibition, it is permeable in cells and tissues and has low toxicity. Shown to have diverse biological activities, such as antiviral FDMV, ASFV, antiparasitic, anticancer and immunomodulatory properties. Shown to reduce bone resorption in embryonic mouse bone explants.

Catalog No. 50-256-2407