E-64

Catalog No. AAJ62933LB0

Supplier: Thermo Scientific Chemicals J62933LB0

Description

Selective and irreversible cysteine protease inhibitor | CAS: 66701-25-5 | C15H27N5O5 | 357.41 g/mol

It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained

Solubility
Soluble in DMSO (25mg/ml), or water (20mg/ml)

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong acids, strong bases.

Specifications

Chemical Identifiers

• CAS: 66701-25-5
• Molecular Formula: C15H27N5O5
• Molecular Weight (g/mol): 357.41
• MDL Number: MFCD00080261,MFCD00080261
• InChI Key: LTLYEAJONXGNFG-HBNTYKKESA-N
• Synonym: d09fgq, l-3-trans-carboxy-oxiran-2-carbonyl-leu-agmatin, trans-epoxysuccinyl-leucylamido-4-guanidino butane, 3-1-4-carbamimidamidobutyl carbamoyl-3-methylbutyl carbamoyl oxirane-2-carboxylic acid, 3-1-4-diaminomethylideneamino butylamino-4-methyl-1-oxopentan-2-yl carbamoyl oxirane-2-carboxylic acid
• PubChem CID: 4641099
• IUPAC Name: 3-[[1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
• SMILES: CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(O)=O)C(=O)NCCCCN=C(N)N

• Color: White
• Quantity: 5 mg
• Beilstein: 1405664
• Sensitivity: Light sensitive
• Solubility Information: Soluble in DMSO (25mg/ml), or water (20mg/ml)
• Optical Rotation: +24° (c=1 in 1N HCl)
• Formula Weight: 357.4
• Physical Form: Powder
• Chemical Name or Material: E-64

Safety and Handling

RTECSNumber	RR0390000
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only