Apexbio Technology LLC E 64d 88321-09-9 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A19035.1

E-64d is a membrane-permeable cysteine protease inhibitor derived from E-64c acting via covalent modification of the proteolytic active site thiol group It demonstrates inhibitory activity primarily against calpain a calcium-dependent cysteine protease involved in diverse cellular processes E-64d readily penetrates intact cells allowing researchers to inhibit intracellular protease activity without disruption In intact platelet models short incubation with E-64d results in persistent suppression of calpain activity even after removal of extracellular inhibitor by washing Experimentally it is commonly utilized to investigate calpain s role in physiological and pathological events particularly in platelets and cellular apoptosis pathways The typical reported IC50 value of E-64d against calpain is approximately 0 5 1 M

Catalog No. 50-000-62851