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Medchemexpress LLC (E)-N-[4-(3-chloro-4-(3-fluorophenyl)methoxy)anilino]-4-(dimethylamino)but-2-enamide | 848133-17-5 | MFCD26792555 | >98.0% | 574.0 g/mol | C31H29ClFN5O3 | 10 MM 1 ML
SDP

Supplier:  Medchemexpress LLC HY10344310MM 1ML

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HKI-357 is an irreversible small-molecule inhibitor of EGFR and ERBB2 used as a research reagent to probe receptor autophosphorylation and downstream signaling pathways. It shows potent cellular activity (reported IC50s ~34 nM and 33 nM) and is provided as a solid or as a ready-to-use DMSO solution for cell signaling studies.

  • Irreversible dual inhibitor of EGFR and ERBB2.
  • Potent activity with IC50s around 34 nM and 33 nM.
  • Suppresses EGFR autophosphorylation (Y1068) and downstream AKT and MAPK signaling.
  • Available as 10 mM solution in DMSO or as solid quantities for flexible dosing.
  • High purity, typically ≥98% (HPLC), suitable for research applications.

Catalog No. 50-002-46335


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