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Medchemexpress LLC (E/Z)-Locostatin | 133812-16-5 | 99.5% | 245.27 | 10 MG
Supplier: Medchemexpress LLC HYW01341110MG
(E/Z)-Locostatin, also known as (E/Z)-UIC-1005, is a racemic form of Locostatin. This potent RKIP inhibitor works by binding to the Raf kinase inhibitor RKIP protein, thereby disrupting its interaction with Raf-1 kinase and G protein-coupled receptor kinase 2. It has been shown to inhibit cell proliferation and migration. It can also aggravate thioacetamide-induced acute liver failure in mice.
- Potent RKIP inhibitor
- Inhibits cell proliferation and migration
- Disrupts interaction of RKIP with Raf-1 kinase
- Disrupts interaction of RKIP with G protein-coupled receptor kinase 2
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