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Cayman Chemical E6446hydrochlorIde 10mg
Supplier: Cayman Chemical 3729610 MG
A TLR7 and TLR9 antagonist (IC50s = 1.78 and 0.01 µM, respectively); selective for TLR7 and TLR9 over TLR4 (IC50 = 10.58 µM); inhibits CpG ODN2216- or RNA40-induced IL-6 production in isolated mouse BMDCs; prevents increases in left ventricle chamber size and cardiac fibrosis in a mouse model of transverse aortic constriction-induced heart failure at 1.5 mg/animal; increases survival and reduces increases in right ventricular systolic pressure and hypertrophy in a rat model of monocrotaline-induced pulmonary hypertension at 10 mg/kg; has been used to enhance the transfection efficiency of cell-penetrating peptides for the delivery of mRNA in vitro
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