Cayman Chemical EchInocystIc AcId 10mg

Supplier:  Cayman Chemical 2747610 MG

A triterpene with diverse biological activities; induces nuclear translocation of the GR and reduces TNF-α-induced NF-κB signaling in HEK293 cells overexpressing GFP-GR; suppresses RANKL-induced NF-κB activation, ERK phosphorylation, and osteoclastogenesis in mouse BMMs at 12.5, 25, and 50 μM; induces neurite outgrowth in Neuro2A cells; decreases escape latency in the Morris water maze and increases the length of neurite processes in the hippocampus of aged mice at 10 mg/kg per day; topical administration reduces TPA-induced expression of COX-2, iNOS, TNF-α, and IL-1β and EAr edema in a mouse model of dermatitis; recovers reductions in femoral bone mineral density and trabecular thickness and number in a rat model of ovariectomy-induced osteoporosis

Catalog No. 50-293-9688