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KRISHGEN BIOSYSTEMS Immunoassay for the estimation of Eculizumab in serum and plasma. Validated against ICH M10. Can be used for generics and biosimilars PK studies. Assay Range: 10 - 640 ng/ml; Sensitivity: 8 ng/ml.
Supplier: KRISHGEN BIOSYSTEMS KBI1024
Pack Size: 1 x 96 wells Background: Eculizumab is used to treat paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and neuromyelitis optica. Eculizumab, sold under the trade name Soliris, binds to binds to terminal complement component 5 (C5), which acts at a late stage in the complement cascade. C5 is part of activation of host cells, helping attract pro inflammatory immune cells. Inhibition of the complement cascade by inhibition of C5 cleavage, impeding inflammation and cell destruction.When activated, C5 is involved in activating host cells, thereby attracting pro-inflammatory immune cells, while also destroying cells by triggering pore formation. This mAb-based Eculizumab ELISA accurately quantifies eculizumab in human samples. If you are looking to use animal samples, please contact us. ELISA Features include a pre-coated plate with break-apart wells, standardisation and Lot to Lot Consistency with Precision CV <15%.
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