AdipoGen EDAR (human):Fc (human) (rec.) (50 µg)

Supplier:  AdipoGen AG40B0116C050

Protein. The extracellular domain of human EDAR (aa 27-183) is fused at the C-terminus to the Fc portion of human IgG1. Source: CHO cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse EDA-A1. Purity: >95% (SDS-PAGE). The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. The Eda gene on the X chromosome is transcribed as multiple splice variants, only two of which code for the receptor-binding C-terminal TNF homology domain. These two variants code for 391- and 389-amino acid-long proteins called EDA1 and EDA2. EDA1 binds EDAR, whereas EDA2 binds to another receptor, XEDAR.

Catalog No. 50-205-3187