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Medchemexpress LLC EG01377 dihydrochloride | 2749438-61-5 | 99.0% | 659.60 | 25 MG
Supplier: Medchemexpress LLC 25MGHY112151A
EG01377 dihydrochloride is a potent, bioavailable, and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. It exhibits antiangiogenic, antimigratory, and antitumor effects by inhibiting vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR.
- Inhibits VEGF-A stimulated tyrosine phosphorylation of VEGF-R2/KDR.
- Reduces HUVEC cell migration and delays VEGF-induced wound closure.
- Reduces network area, length, branching points, and VEGF-induced angiogenesis.
- Combines with VEGFA to reduce A375P (malignant melanoma) spheroid outgrowth.
- Blocks TGFβ production by Nrp1+ regulatory T-cell SMAD3/AKT (Tregs).
- Exhibits a half-life of 4.29 h in mice, supporting once-daily dosing.
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