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Genscript Corporation Antibody Protein Proteins Proteins 10 UG 1/EA
Supplier: Genscript Corporation Z0320210
EGF Receptor also known as ERBB ERBB1 and HER1 is a type I transmembrane protein belonging to the tyrosine protein kinase family. It belongs to a family of tyrosine kinase receptors including Human EGF Receptors (HER) 2 3 and 4 which all play important roles in cell growth and differentiation. Their primary ligands are EGF Heparin-Binding EGF and Transforming Growth Factor Alpha. Upon ligand binding EGFR undergoes asymmetric dimerization composed of an “activator” and a “receiver”. EGFR and its family members are disregulated in numerous cancers. In particular EGFR is overexpressed in many epithelial solid tumors. Evidence suggests EGFR is an excellent target for pharmacologic intervention in Non Small Cell Lung Cancer (NSCLC) due to its high level of expression and prominent role in tumor growth and metastasis.
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