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AdipoGen EGFR Soluble human rec
Supplier: AdipoGen AG40T0041C025
Protein. Human EGFR 629aa is fused at the C-terminus to a Strep-tag. Source Sf9 cells. Lyophilized. Purity >90% SDS-PAGE. EGFR has been shown to bind a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, heparin-binding EGF and neuregulin-2 in the absence of a co-receptor. Ligand binding induces EGFR homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR signaling has been shown to regulate multiple biological functions including cell proliferation, differentiation, motility and apoptosis. In addition, EGFR signaling has also been shown to play a role in carcinogenesis.
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