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Genscript Corporation EGFRVIIIBiotin HisAvi Hum
Supplier: Genscript Corporation Z03941100
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors often as a consequence of gene amplification Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements with the most common extracellular domain mutation being EGFRvIII This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand
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