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Cayman Chemical eIF2a ActIvatr 2 5mg
Supplier: Cayman Chemical 401305 MG
An activator of EIF2AK1/HRI; activates HRI and induces eIF2α phosphorylation in a surrogate cell-based reporter assay; selectively inhibits the proliferation of CRL-2813 cells over NIH3T3 fibroblasts (IC50s = 0.46 and 3.4 µM, respectively); selectively inhibits the proliferation of CRL-2813 cells transiently transfected with non-targeted siRNA over CRL-2813 cells transiently transfected with HRI-targeted siRNA (IC50s = 0.66 and 5 µM, respectively); increases mRNA expression and protein levels of the eIF2α target CHOP in CRL-2813 cells at 5 µM
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