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Medchemexpress LLC Elabela(19-32) (TFA) | 98.8% | 1821.05 | 5 MG
SDP

Catalog No. 5000422917
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Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to the apelin receptor (APJ). It activates the Gαi1 and β-arrestin-2 signaling pathways, induces receptor internalization, and has demonstrated effects on cardiovascular function, including reducing arterial pressure and exerting positive inotropic effects on the heart.

  • Binds to apelin receptor (APJ)
  • Activates Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM, respectively
  • Induces receptor internalization with an EC50 of 36 nM in HEK293 cells
  • Reduces arterial pressure
  • Exerts positive inotropic effects on the heart
  • Has a Ki of 0.93 nM for binding of radioligand apelin-13[Glp65, Nle75, Tyr77][125I]
  • Rapidly metabolized in rat plasma (t1/2<2 min)

Catalog No. 50-004-22917 Supplier Medchemexpress LLC Supplier No. HYP2106A5MG
May include imposed supplier surcharges.
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Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to the apelin receptor (APJ). It activates the Gαi1 and β-arrestin-2 signaling pathways, induces receptor internalization, and has demonstrated effects on cardiovascular function, including reducing arterial pressure and exerting positive inotropic effects on the heart.

  • Binds to apelin receptor (APJ)
  • Activates Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM, respectively
  • Induces receptor internalization with an EC50 of 36 nM in HEK293 cells
  • Reduces arterial pressure
  • Exerts positive inotropic effects on the heart
  • Has a Ki of 0.93 nM for binding of radioligand apelin-13[Glp65, Nle75, Tyr77][125I]
  • Rapidly metabolized in rat plasma (t1/2<2 min)

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