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Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 25 MG
Supplier: Medchemexpress LLC 25MGHY19822A
Elacestrant dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 nM for ERα and 870 nM for ERβ. It can also inhibit the growth of ER+ breast cancer cell lines in vitro and in vivo. This compound is designed for high-speed applications in research settings.
- Inhibits ERα expression with an EC50 of 0.6 nM in MCF-7 cells.
- Decreases expression of progesterone receptor in MCF7 and T47D cell lines.
- Antagonizes E2-mediated uterine stimulation in a dose-dependent manner in vivo.
- Induces complete tumor growth inhibition in mice.
- Maintains tumor growth inhibition for 4 weeks after withdrawal.
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