Apexbio Technology LLC Elacridar(Synonyms: GF120918, GG918, GW0918, GF-120918, GG-918, GW-0918), 10mM (in 1mL DMSO), CAS: 143664-11-3.

Supplier:  Apexbio Technology LLC A33845.1

Elacridar (CAS 143664-11-3) is a potent inhibitor of P-glycoprotein (P-gp) a transmembrane efflux transporter belonging to the MDR/TAP subfamily P-gp actively exports diverse xenobiotics and drugs from cells significantly influencing drug bioavailability and distribution Elacridar inhibits P-gp with an IC50 of approximately 193 nM and markedly reduces transporter activity in P-gp-overexpressing MDCKII cell models at concentrations as low as 1 M In mice elacridar administration (10 mg/kg) enhances brain penetration of P-gp substrates such as sunitinib Thus elacridar is extensively used in biomedical research to study drug transport mechanisms and multidrug resistance

Catalog No. 50-000-60272