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Cayman Chemical Elafbrnor 10mg
Supplier: Cayman Chemical 2350810 MG
An agonist of PPARα and PPARδ; increases HDL secretion and expression of lipid-related genes ABCA1, PLIN-2, and ABHD5 in Caco-2/TC7 cells in a PPARα-dependent manner; decreases levels of plasma triglycerides and total cholesterol while increasing plasma HDL and expression of Acox1 in the liver of ApoE2-KI wild-type, but not PPARα knockout, mice fed a Western diet when administered at a dose of 10 mg/kg; reduces diet-induced macro- and micro-steatosis in a PPARα-deficient mouse model of non-alcoholic steatohepatitis; reduces cholesterol and triglyceride accumulation as well as macrovesicular steatosis in the liver of insulin-resistant db/db mice fed the MCD diet
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