Cayman Chemical EldecalcItol 10mg

Supplier:  Cayman Chemical 3371310 MG

A derivative of calcitriol; induces calcium release in an in vitro bone mobilization assay using isolated mouse calvaria at 10 nM; reduces LPS-induced pyroptosis and increases in hydrogen peroxide and protein levels of the NLRP3 inflammasome, caspase-1, and IL-1β in primary human gingival fibroblasts at 50 nM; induces apoptosis and cell cycle arrest at the G0/G1 phase in, and inhibits migration of, SCC-15 and CAL 27 cells at 0.4 nM; decreases tumor volume in an SCC-15 mouse xenograft model at 0.5 UG/kg twice per week; decreases serum PTH levels and increases serum calcium levels, bone mineral density, and bone strength in a cynomolgus monkey model of osteoporosis induced by ovariectomy at 0.3 UG/kg

Catalog No. 50-294-9705