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Apexbio Technology LLC Elesclomol (STA-4783) 488832-69-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A43865.1
Elesclomol (STA-4783 CAS 488832-69-5) is a small molecule identified through phenotype-based screens for apoptotic activity which induces apoptosis in cancer cells by elevating intracellular reactive oxygen species (ROS) Its primary cellular target is mitochondrial electron transport disruption of which results in rapid accumulation of oxidative stress exceeding adaptive thresholds and ultimately triggering apoptotic cell death Elesclomol demonstrates antitumor activity across diverse human tumor xenograft models and is currently studied as an investigational anticancer compound capable of extending progression-free survival
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