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Cayman Chemical ElIglustathemItartrate 10mg
Supplier: Cayman Chemical 2148710 MG
A glucosylceramide synthase inhibitor (IC50 = 40 nM for inhibition of glucosylceramide production in K562 cells); selective for glucosylceramide synthase over α-glucosidase I and II, α-1,6-glucosidase, lysosomal glucocerebrosidase, non-lysosomal glucosylceramidase, sucrase, and maltase (IC50s = >10 µM for all); decreases GM1 and GM3 cell surface levels in K562 and B16/F10 cells (IC50s = 24 and 29 nM, respectively); decreases glucosylceramide levels in the liver and lungs of D409V/null mice
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