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Apexbio Technology LLC Eltrombopag 496775-61-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B21595.1
Eltrombopag is a small molecule orally bioavailable non-peptide agonist targeting the thrombopoietin (TPO) receptor also known as c-Mpl receptor Upon activating this receptor pathway eltrombopag promotes intracellular signaling leading to increased proliferation and differentiation of megakaryocyte progenitor cells thereby stimulating platelet production (thrombopoiesis) In biochemical assays eltrombopag shows potent activity exhibiting an IC50 value of approximately 0 69 M As a research tool this compound is utilized widely in studies investigating mechanisms regulating platelet homeostasis thrombocytopenia-related diseases and efforts to elucidate novel therapeutic strategies targeting hematopoietic lineage differentiation
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