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Apexbio Technology LLC Elvitegravir (GS-9137) 697761-98-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A40705.1
Elvitegravir (GS-9137) is an integrase inhibitor targeting HIV-1 which impedes viral DNA integration during the replication cycle of human immunodeficiency virus type 1 (HIV-1) Its mechanism involves inhibition of the integrase enzyme-mediated DNA strand transfer reaction thereby preventing the insertion of viral genetic material into host genomic DNA and subsequently decreasing viral replication Reported inhibitory concentrations (IC50) against HIV-1 integrase range approximately from 7 to 8 nM Besides its application in HIV-1 research Elvitegravir demonstrates inhibitory effects against other retroviral integrases such as murine leukemia virus (MLV) and simian immunodeficiency virus (SIV) making it suitable for broader antiviral research use
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