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Cayman Chemical EmamectIn B1a 5mg
Supplier: Cayman Chemical 240605 MG
An orally bioavailable and ATP-competitive multi-AGC kinase inhibitor inhibits Akt1 2 and 3 (IC50s 38 402 and 50 nM respectively) inhibits p70S6K PKA and ROCK1 and ROCK2 (IC50s 3-8 nM) antiproliferative against cancer cell lines with genetic mutations in PI3K-Akt-mTOR or RAS-RAF pathways (GI50s 1.54-3.77 M) inhibits growth of MES-SA uterine sarcoma and BT474 breast cancer xenografts in mice (50 mg/kg p.o.) inhibits ROCK-dependent phosphorylation of MLC2 over a 24-hour period in 4599 mouse melanoma cells (EC50 0.1 M) reduces motility of 4699 melanoma cells in murine xenograft model
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