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Cayman Chemical EmavusertIb 50mg

Supplier: Cayman Chemical 3684550 MG
An IRAK4 inhibitor (IC50 = 31.7 nM); selective for IRAK4 over FLT3, Cdk2, Aurora A kinase, GSK3β, and MUSK at 1 µM; inhibits TLR2-, TLR5-, or IL-1R-mediated IL-6 release in isolated human whole blood (IC50s = 989, 696, and 1,375 nM, respectively); reduces tumor volume in an OCI-Ly3 DLBCL mouse xenograft model from 25-200 mg/kg
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