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Apexbio Technology LLC Embelin 550-24-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A82355.1
Embelin (CAS 550-24-3) is a natural benzoquinone derivative isolated from plants of the genus Embelia functioning as an inhibitor of X-linked inhibitor of apoptosis protein (XIAP) with an IC50 value of 4 1 M XIAP negatively regulates apoptosis by inhibiting caspase activation Embelin promotes apoptosis by interrupting XIAP-caspase interaction activating apoptotic pathways in tumor cells expressing elevated XIAP levels Additionally embelin can inhibit the NF- B signaling cascade through suppression of IKK activation thereby downregulating NF- B-mediated anti-apoptotic and metastatic gene expression In animal models embelin demonstrates anti-tumor properties by attenuating tumorigenesis related to inflammation-driven colorectal cancer through modulation of IL-6/STAT3 pathway signaling
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