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MilliporeSigma™ Calbiochem™ Radicicol, Diheterospora chlamydosporia

Catalog No. 553400500UG Shop All MilliporeSigma Products
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Quantity:
500 μg

Description

A cell-permeable, ATP-site binding, and irreversible antifungal macrocyclic lactone antibiotic that acts as a protein tyrosine kinase inhibitor

Inhibits p60v-src kinase activity (IC50 = 0.27 nM). Inhibits the expression of COX-2 (IC50 = 27 nM) without affecting COX-1 expression in LPS-stimulated macrophages. Disrupts K-Ras-activated signaling pathways by selectively depleting Raf kinase. Inhibits tyrosine phosphorylation of p53/56lyn in LPS-stimulated macrophages. Suppresses NIH/3T3 cell transformation by diverse oncogenes such as src, ras, and mos in part by blocking the key signal transduction intermediates such as MAP kinase and GAP-associated p62. Also exhibits anti-angiogenic activity in vivo. Inhibits Wnt-5A expression in dermal papilla cells (IC50 = 190 nM).
TRUSTED_SUSTAINABILITY

Specifications

Content And Storage 2-8°C
Purity or Quality Grade ≥98% by HPLC
Quantity 500 μg
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