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MilliporeSigma™ Complement C1s, Human, Activated, Two-Chain Form, Protein

Catalog No. 204879250UG
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Quantity:
250 μg

Description

Native, human, activated C1s complement component. Present in human serum at 31μg/mL. Nonactivated C1s is found in circulating blood plasma as a Ca2+-dependent dimer in association with one C1q molecule and two C1r molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r protein is cleaved to form activated C1r enzyme. Dimeric C1r enzyme cleaves, and thus activates, each C1s molecule into two disulfide-linked fragments of M.W. 59kDa and 28kDa. The 28kDa peptide contains the C1s enzymatic active site. Activated C1s continues activation via classical pathway by cleaving, and thus activating, C2 and C4.
TRUSTED_SUSTAINABILITY

Specifications

Concentration Concentration on Label
Formulation In 130mM NaCl, 50mM sodium phosphate, pH 7.2.
Purification Method SDS-PAGE
Quantity 250 μg
Immunogen Complement C1s
Storage Requirements Following initial thaw, aliquot and freeze (−70°C).
Regulatory Status RUO
Structural Form Two-Chain Form
Species Human
Recombinant Native
Form Liquid
Purity or Quality Grade ≥95%
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