MilliporeSigma™ Complement C2, Human, Protein

Catalog No.	Quantity
20-488-250UG	50 μg

Catalog No. 20-488-250UG Supplier MilliporeSigma™ Supplier No. 20488250UG

Description

Native, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20μg/mL. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63kDa C-terminal fragment, and C2b, the 30kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.

Specifications

• Concentration: Concentration on Label
• Formulation: In PBS, pH 6.0.
• Purification Method: SDS-PAGE
• Quantity: 50 μg
• Immunogen: Complement C2
• Storage Requirements: Following initial thaw, aliquot and freeze (−70°C).
• Regulatory Status: RUO
• Species: Human
• Recombinant: Native
• Form: Liquid
• Purity or Quality Grade: ≥90%