MilliporeSigma™ Complement C4b, Human, Protein

Catalog No.	Quantity
20-489-7250UG	250 μg

Catalog No. 20-489-7250UG Supplier MilliporeSigma™ Supplier No. 204897250UG

Description

Native, human C4b complement component. Cleavage of the C4 α-chain at peptide bond 77 by activated C1 enzyme results in the production of C4a (M.W. 8,758) and C4b (M.W. 193,000) fragments. The C4b fragment is a glycoprotein composed of the modified C4 α-chain (α') and intact β- and γ-chains. Like C3b, C4b has the transient ability to form a covalent ester bond with a variety of target cell surfaces. Once bound to the target surface, C4b becomes an essential non-enzymatic subunit of the classical pathway C3 cleaving enzyme (C4b,C2a). In addition, surface bound C4b has opsonic and immune adherence activities which are mediated via binding to the CR1 (CD35) complement receptor which is found on a variety of inflammatory cells.

Specifications

• Concentration: Concentration on Label
• Formulation: In PBS, pH 7.2.
• Purification Method: SDS-PAGE
• Quantity: 250 μg
• Immunogen: Complement C4b
• Storage Requirements: Following initial thaw, aliquot and freeze (−70°C).
• Regulatory Status: RUO
• Species: Human
• Recombinant: Native
• Form: Liquid
• Purity or Quality Grade: ≥95%