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MilliporeSigma™ Complement C5, Human, Protein
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Quantity:
250 μg
Description
Native, human C5 complement component. Glycoprotein composed of two non-identical subunits of M.W. 120kDa (α) and 75kDa (β) linked by disulfide bonds. Present in normal human serum at 70μg/mL. Activation of complement via either the classical or alternative pathway can result in the assembly of C5-cleaving enzymes (C5 convertases) on target surfaces. Both C5 convertases cleave the C5 α-chain at peptide bond 74 resulting in production of C5a (M.W. 11,200) and C5b fragments (M.W. 185,000). Released C5a peptide is one of the three complement-derived anaphylatoxins. C5b fragment combines with C6, C7, C8, and C9 to form lytic C5b-9 complement membrane attack complex (MAC).

Specifications
Specifications
Concentration | Concentration on Label |
Formulation | In PBS, pH 7.2. |
Purification Method | SDS-PAGE |
Quantity | 250 μg |
Immunogen | Complement C5 |
Storage Requirements | Following initial thaw, aliquot and freeze (−70°C). |
Regulatory Status | RUO |
Species | Human |
Recombinant | Native |
Form | Liquid |
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