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MilliporeSigma™ Complement C5, Human, Protein

Catalog No. 204888250UG Shop All MilliporeSigma Products
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20-488-8250UG 250 μg
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Catalog No. 20-488-8250UG Supplier MilliporeSigma™ Supplier No. 204888250UG
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Description

Native, human C5 complement component. Glycoprotein composed of two non-identical subunits of M.W. 120kDa (α) and 75kDa (β) linked by disulfide bonds. Present in normal human serum at 70μg/mL. Activation of complement via either the classical or alternative pathway can result in the assembly of C5-cleaving enzymes (C5 convertases) on target surfaces. Both C5 convertases cleave the C5 α-chain at peptide bond 74 resulting in production of C5a (M.W. 11,200) and C5b fragments (M.W. 185,000). Released C5a peptide is one of the three complement-derived anaphylatoxins. C5b fragment combines with C6, C7, C8, and C9 to form lytic C5b-9 complement membrane attack complex (MAC).
TRUSTED_SUSTAINABILITY

Specifications

Concentration Concentration on Label
Formulation In PBS, pH 7.2.
Purification Method SDS-PAGE
Quantity 250 μg
Immunogen Complement C5
Storage Requirements Following initial thaw, aliquot and freeze (−70°C).
Regulatory Status RUO
Species Human
Recombinant Native
Form Liquid
Purity or Quality Grade ≥95%
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